which differs from physiological mitophagy in vivo. Thus, while major insights have been possible from tractable short-lived model organisms, the question of how autophagy pathways are modulated in ...

Within plaques, macrophages undergo endoplasmic reticulum stress(ERS) in response to lipid stimulation, directly impacting mitochondrial function. Mitophagy serves as the primary pathway for ...

This article focuses on the role of the mitophagy receptor FUNDC1 in maintaining mitochondrial function and kidney ... These functions indicate that FUNDC1 is the intersection of multiple signal ...

The drugs in its preclinical pipeline induce mitophagy and activate a pathway known as the PINK1/Parkin pathway that governs mitochondrial quality control. They bind to an undisclosed, novel target.

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AICAR 5-aminoimidazole-4-carboxamide ribonucleotide is a peptide that has garnered interest within the scientific community due to its possi ...

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