The heart is the first organ to form and function in the embryo, and all subsequent events ... [2] Despite these detailed descriptions of abnormal cardiac phenotypes, important gaps in our ...

Introduction: After a myocardial infarction (MI), cardiac fibroblasts are activated to deposit extracellular matrix that while prevents acute cardiac rupture in the short-term, causes long-term ...

To test this, we examined how environmental noise, a major contributor to human sleep disruption, applied during the murine inactive/light phase (noise-induced sleep disruption; NISD) impacts sleep ...

as an effective inhibitor of cardiac fibrosis. ART improved cardiac function in various mouse models of heart failure. Cardiac fibroblasts (CFs) can become activated myofibroblasts in response to ...

In this study, we identified the anatomical patterns of cardiac ... mice at E10.5. After 3 days, we harvested the embryos and observed that all the embryos with ablated fibroblasts (Pdgfra-CreER+/-; ...

Chongqing Key Laboratory of Human Embryo Engineering and Precision Medicine, Center for Reproductive Medicine, Women and Children’s Hospital of Chongqing Medical University, Chongqing 400013, China ...

Scientists there say they've successfully reversed liver fibrosis in mice. Reporting recently in the journal Nature Communications, the team say they've discovered a genetic pathway that ...