The heart is the first organ to form and function in the embryo, and all subsequent events ... [2] Despite these detailed descriptions of abnormal cardiac phenotypes, important gaps in our ...

Introduction: After a myocardial infarction (MI), cardiac fibroblasts are activated to deposit extracellular matrix that while prevents acute cardiac rupture in the short-term, causes long-term ...

as an effective inhibitor of cardiac fibrosis. ART improved cardiac function in various mouse models of heart failure. Cardiac fibroblasts (CFs) can become activated myofibroblasts in response to ...

Chongqing Key Laboratory of Human Embryo Engineering and Precision Medicine, Center for Reproductive Medicine, Women and Children’s Hospital of Chongqing Medical University, Chongqing 400013, China ...

Scientists there say they've successfully reversed liver fibrosis in mice. Reporting recently in the journal Nature Communications, the team say they've discovered a genetic pathway that ...

However, dysregulated fibroblast activity is also associated with excessive scarring (fibrosis) and impaired wound healing, especially over time. Cartalax, by virtue of its regulatory properties, is ...

aDepartment of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States bRobert and Arlene Kogod Center on Aging, Mayo Clinic, 200 ...

Gene manipulation: it is seminal to use a suicide gene to ablate embryonic stem cell (ESC) misbehavior. Recent progress has succeeded in reprogramming autologous fibroblasts to be pluripotent ESC ...