There was no meaningful protection from major cardiac events after MI, reported investigators of the multinational placebo-controlled trial that is challenging common clinical practice.
Conclusions: Both acute and chronic EMPA treatment significantly reduced infarct size. We showed for the first time that EMPA reduced no-reflow in an acute rat myocardial ischemia/reperfusion model.
Background: Mitochondrial dysfunction is linked to myocardial ischemia-reperfusion (I/R) injury. Checkpoint kinase 1 (CHK1) could facilitate cardiomyocyte proliferation and cardiac repair post ...