Genesis Therapeutics Inc. has divulged phosphatidylinositol 3-kinase alpha (PI3Kα) (H1047R mutant) inhibitors reported to be useful for the treatment of cancer.

Background: Recent studies in both human genetics and mouse models have highlighted the significance of phosphatidylinositol (PI) in the progression of fatty liver disease (FLD). Despite this, the ...

Dysregulated cell signaling underlies various diseases, emphasizing the importance of understanding these pathways for ...

Verge Analytics Inc. (dba Verge Genomics) has prepared and tested new hydrazone and pyrazole 3H-imidazo(4,5-b)pyridine compounds acting as 1-phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) ...

To investigate the downstream signalling pathways, the authors carried out a series of experiments using selective inhibitors of the phosphatidylinositol 3-kinase (PI3K)–Akt–GSK3β pathway and ...

meduniwien.ac.at The phosphatidylinositol-3 kinases (PI3Ks) and the mammalian target of rapamycin (mTOR) pathway have long been recognised as critically regulating metabolism, growth or survival.

*仅供医学专业人士阅读参考国际大型EQA项目揭秘PIK3CA基因检测在乳腺癌治疗中的关键角色。浸润性乳腺癌（IBC）是一种侵袭性生长的乳腺实质恶性肿瘤[1]。其中激素受体阳性（HR+）/人表皮生长因子受体2阴性（HER2-）乳腺癌是最常见的亚型[2] ...

We report here for the first time that high-fat feeding augments plasma LPS at a concentration sufficient to increase body weight, fasted glycemia, and inflammation. LPS infusion in normal diet ...

Arne Gericke is the Dean of Undergraduate Studies ad interim, Director of the Office of Undergraduate Research, and a Professor of Chemistry & Biochemistry. The research in my lab is generally ...

Lipids, or fats, are essential to life. They form the membranes around cells, protecting them from the outside. In nature, there is an enormous diversity of lipids, with each organism having its ...

Adhesives are everywhere, from the tape used in households to the bonding materials in vehicles and electronics. The search for stronger, more adaptable adhesives is ongoing and may come down to ...