Despite this knowledge, the precise mechanism underlying the formation of these nascent membrane structures remains poorly understood. To gain insights into this process, researchers at the ...
These insights not only elucidate the anti-CSCs mechanism of the lead compound ... facilitating the development of new PROTAC molecules targeting EGFR and CDK4 degradation.
A research team has discovered a novel mechanism essential for initiating autophagy. The study highlights the role of ZDHHC13, an enzyme that palmitoylates ULK1, in triggering autophagy.
Targeted protein degradation (TPD) is getting a lot of attention as a promising modality to treat a variety of diseases from cancer to Alzheimer’s. By taking proteins down the cell’s own degradation ...