In fact, each gene in cellular DNA contains the code for a unique protein structure. Not only are these proteins assembled with different amino acid sequences, but they also are held together by ...
Because a protein’s structure helps determine its biological function, the new structures, along with those available from cryo-EM, could revolutionize biology and drug discovery. To be useful ...
The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...
Our research focuses on studies on the molecular structure and mechanism of proteins, recently mostly on the endoplasmic reticulum proteins ... We also collaborate on various structural biology ...
Determining a protein’s three-dimensional structure based solely on its one-dimensional amino acid sequence has stood as a grand challenge in the field of biology for over half a century.
One of biology's biggest mysteries has been solved ... Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction) then compares these predictions with 3-D ...
With MassiveFold, scientists have unlocked AlphaFold's full potential, making high-confidence protein predictions faster and more accessible, fueling breakthroughs in biology and drug discovery.
As merely solving a structure provides only a superficial understanding of a protein’s function, we emphasize complementary techniques that provide a more complete understanding of a protein’s ...