Determining a protein’s three-dimensional structure based solely on its one-dimensional amino acid sequence has stood as a grand challenge in the field of biology for over half a century.
Because a protein’s structure helps determine its biological function, the new structures, along with those available from cryo-EM, could revolutionize biology and drug discovery. To be useful ...
The new Dogma meets Thomas Kuhn’s definition of a paradigm shift. The DNA/RNA Dogma is sufficiently unprecedented to attract ...
In fact, each gene in cellular DNA contains the code for a unique protein structure. Not only are these proteins assembled with different amino acid sequences, but they also are held together by ...
The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...
Nobel Prize in Chemistry was awarded for AI innovations in protein structure prediction, revolutionising drug development.
Understanding protein–ligand interactions is fundamental to molecular biology and biochemistry. These interactions are at the ...
Researchers have found an ancient protein fold that might explain how life’s basic building blocks became the complex systems ...
A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the ...
Nobel Prize in Chemistry highlights AI-driven breakthroughs in computational protein design and structure prediction. Tools ...