Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL), a commercial stage biotechnology company focused on hematologic disorders and cancer, today announced that the U.S. Food and Drug Administration (FDA) has ...

【导读】环状RNA能够调节巨噬细胞的细胞质溶质性死亡（即细胞焦亡），这有可能促进炎症和基质金属蛋白酶（MMP）活性在腹主动脉瘤（AAA）中的协同作用。但环状RNA在调节AAA中巨噬细胞细胞质溶质性死亡方面的作用尚不明确。11月27日，南方医科大学何翔 ...

ZyVersa Therapeutics (ZVSA) announces newly published data demonstrating that stroke-related cardiovascular injury and dysfunction is induced by AIM2 inflammasome activation and pyroptosis in the ...

近日，中国科学院上海有机化学研究所生物与化学交叉研究中心许代超研究员在Cell Press细胞出版社期刊Trends in Cell Biology 发表了题为“Emerging roles of palmitoylation in pyroptosis”的综述 ... 将棕榈酸连接到靶蛋白半胱氨酸残基）在NLRP3炎症小体和GSDMD激活等多个层面 ...

Shanghai Tenth People’s Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, Shanghai 200331, P. R. China Shanghai Tenth People’s Hospital, ...

It was further found that ZTY could inhibit the expression of ASC, Nlrp3, Caspase-1 and GSDMD mRNA in Caspase-1 mediated proptosis pathway. At the transcriptional level, ZTY can also inhibit the ...

To assess pyroptosis induced by black phosphorus nanosheets (BPNSs), flow cytometry with ... The membranes were then incubated overnight at 4 °C with primary antibodies (β-actin, NLRP3, ASC, Caspase1, ...