A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote ...

However, there have been no convincing markers or precise molecular mechanisms to determine TAM functions in ... As breast cancer mainly occurs in female, female mice at 8-12 weeks age were used for ...

It may be a useful approach by inhalation and an essential approach by intravenous administration, as this allows a reduction in uptake by macrophages of the liver and spleen. Therapeutic vaccines ...

Even in animal models, data suggest that the M1–M2 dichotomy is an oversimplification of a macrophage polarization ... While diversity in molecular markers adds complexity to the interpretation ...

The spleen is a key component of the immune system. It filters old blood cells, bacteria, tumor cells out of the blood and breaks them down. The macrophages then get rid of them. Historian Allan ...