In this valuable study, the authors used an elegant genetic approach to delete EED at the post-neural crest induction stage. The usage of the single-cell RNA-seq analysis method is extremely suitable ...

Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation and increased fracture risk. In vitro studies showed that inflammation induces bone erosion and inhibits bone ...

Tour de France Femmes stage winner Cédrine Kerbaol has left Ceratizit-WNT after UCI rules allowed her to terminate her contract early after the German team not initially appearing on the UCI list ...

Estrogen plays an important role in bone biology, best illustrated by three points of observations: Although both ESRs are identified in osteoblasts (cells that make bone), osteoclasts (cells that ...

Police warn of a crime spree involving groups stealing FedEx deliveries.

To date, it is unclear, which therapeutic approach is best suited to achieve erosion repair. Direct stimulation of osteoblasts by parathyroid hormone has not led to significant erosion repair ...

Sclerostin and DKK1 are two critical, negative regulators of WNT signaling in osteoblasts and of bone metabolism. By targeting both proteins, AGA2118 is thought to prevent compensatory increase of ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Muscle injury induces expression of myokines ...