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In an MTAP-deleted mouse xenograft model of non-small cell lung cancer, Apeiron found that GTA182 induced sustained tumor regression with no loss of body weight. The drug also demonstrated brain ...
In vivo, knock-down of CD147 in MiaPaCa2 cells by inducible short hairpin RNA (shRNA)-mediated CD147 silencing reduced invasiveness through the chorioallantoic membrane of chick embryos (CAM assay) ...