Delve into the field of miRNA with 7 promising companies with miRNA-focused candidates in the pipeline, from oncology to neurodegeneration.

Cross-species host–pathogen or mutualistic RNA communication, especially through extracellular vesicles, can have important applications, including gene silencing in agriculture and RNA-based ...

Various gene silencing technologies like siRNA, miRNA, ribozymes, DNAzymes have shown promise as therapeutics agents against viral diseases. RNAi-based drugs against viruses such as ebola virus ...

In SNALPs, the backbone-modified siRNA is encapsulated within a closed shell of a cationic-zwitterionic lipid bilayer, furnished with an outer PEG shield (Figure 2A). The lipid bilayer contains a ...

Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada Department of Biochemistry Microbiology and Immunology, Faculty of Medicine, University of ...

Having developed 5 of the 6 RNAi medicines on the market, Alnylam is setting the example for siRNA therapeutics and ... From brand-new data on microRNA therapeutic potential to groundbreaking ...

北京时间10月7日，瑞典卡罗琳斯卡医学院宣布，将2024年诺贝尔生理学或医学奖授予美国科学家维克托·安布罗斯(Victor Ambros)和加里·鲁夫坎(Gary Ruvkun)，以表彰他们发现了微小核糖核酸（microRNA，以下简称miRNA）及其在转录后基因调控中的作用。 众所周知，在新药蓬勃发展的今天，小核酸药物被认为是将带来“除小分子药和抗体药之外的第三次制药浪潮”的关键。随着诺贝尔奖花 ...

Echocardiography and HE staining were performed to evaluate myocardial infarct size in each group. The expression of microRNA-144-3p and microRNA-214-3p, LC3-II, p62/SQSTM1, phosphatase, and PTEN was ...