Delve into the field of miRNA with 7 promising companies with miRNA-focused candidates in the pipeline, from oncology to ...

Various gene silencing technologies like siRNA, miRNA, ribozymes, DNAzymes have shown promise as therapeutics agents against viral diseases. RNAi-based drugs against viruses such as ebola virus ...

北京时间10月7日，瑞典卡罗琳斯卡医学院宣布，将2024年诺贝尔生理学或医学奖授予美国科学家维克托·安布罗斯(Victor Ambros)和加里·鲁夫坎(Gary Ruvkun)，以表彰他们发现了微小核糖核酸（microRNA，以下简称miRNA）及其在转录后基因调控中的作用。 众所周知，在新药蓬勃发展的今天，小核酸药物被认为是将带来“除小分子药和抗体药之外的第三次制药浪潮”的关键。随着诺贝尔奖花 ...

In SNALPs, the backbone-modified siRNA is encapsulated within a closed shell of a cationic-zwitterionic lipid bilayer, furnished with an outer PEG shield (Figure 2A). The lipid bilayer contains a ...

RNA干扰疗法是目前小核酸药物领域最受关注的存在，其中除了熟知的siRNA外，miRNA也是该疗法的主要构成之一。 对比siRNA，miRNA在功能上的特定优势 ...

Having developed 5 of the 6 RNAi medicines on the market, Alnylam is setting the example for siRNA therapeutics and ... From brand-new data on microRNA therapeutic potential to groundbreaking ...

Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada Department of Biochemistry Microbiology and Immunology, Faculty of Medicine, University of ...