LMU researchers have investigated how cationic polymers organize on a molecular level when transporting RNA drugs.

Potent siRNAs against B4GALT1 were designed in silico and screened in vitro (Huh7 cells, primary mouse, human hepatocytes) as well as in vivo (C57BL/6 mice) for the selection of a lead Galomic siRNA.

In SNALPs, the backbone-modified siRNA is encapsulated within a closed shell of a cationic-zwitterionic lipid bilayer, furnished with an outer PEG shield (Figure 2A). The lipid bilayer contains a ...

Researchers from Ludwig Maximilian University of Munich presented a study in Nano Letters on the molecular organization of ...

LMU researchers have investigated how cationic polymers organize on a molecular level when transporting RNA drugs.

Here, the authors demonstrate a multiplexed combinatorial screening of thousands of siRNA formulations through highthroughput single-cell gene silencing, discovering the most effective anti-cancer ...

RNA therapeutics promise rapid, personalized and flexible treatments against multiple diseases. In this article, we will ...

This valuable study reports the first characterization of the CG14545 gene in Drosophila melanogaster, which the authors name "Sakura." Acting during germline stem cell fate and differentiation, ...

Given their non-migratory nature within the mineralized matrix, their unique dendrites are crucial for cell-to-cell communication in response to both intracellular and extracellular stimuli, such as ...

Hamilton, Bermuda, Sept. 27, 2024 (GLOBE NEWSWIRE) -- Certification to ISO 13485 extended to also include production process Supports Bentrio growth strategy together with strategic contract ...