Background: The water channel aquaporin 4 (AQP4) is abundantly expressed in astrocytes. There is now compelling evidence that AQP4 may contribute to an unfavorable course in brain edema.

Pericytes regulate vascular constriction. Within the brain-wide perivascular space, a polarized astrocyte phenotype with AQP4 expression is essential for the functioning of the glymphatic system.

This review summarizes the association between the disruption of the BBB and the activation of astrocytes in epilepsy via ...

and by promoting perivascular inflammation and astrocyte and myelin injury. The bidirectional water channel AQP4 is an integral part of the BBB and the blood–CSF barrier. The channel is ...

The possible link between neuroinflammation and AQP4 was advertised with neuromyelitis optica (NMO), a demyelinating disease. NMO is a pathological condition characterized by abnormal signals most ...