衰老对于生命来说几乎是不可避免的，尤其是在人类中，古往今来无数人尝试过永生，上到帝王将相，下到贩夫走卒，不过都失败了。不可逆转的衰老不仅带来老年性疾病，还会带来身体机能直观的下降，让人感觉到无可奈何。

In terms of regulating inflammation, SIRT1 interacts with the PI3K/Akt pathway and HIF-1α, illustrating its comprehensive role in ... On the other hand, SIRT1 activates AMPK by deacetylating liver ...

Coagulation factor X performs its' function through increasing the phosphorylation and activation of ERK1/2 (ERK can also enhance the angiogenesis of the tumour) and AKT in macrophages. After that, ...

The residues Tyr14 and Ser80 are the two phosphorylation sites. The residues Cys133 ... TGFβ1, Th17/Treg disruption, NOXs, AKT, Wnt/β-catenin, and ROS.

Importantly, SIRT1 and USP7 regulate the activity ... In addition to PI3P lipids, activation of AKT/PKB requires phosphorylation on a specific residue by the phosphoinositide-dependent kinase ...

Surprisingly, P-TEFb exhibits Ser5 phosphorylation activity in vitro. The mechanism garnering Ser2 specificity to P-TEFb remains elusive and hinders understanding of the transition from transcription ...