Studies in three different transgenic mouse models suggest that the amyloid β-protein contributes to memory loss in Alzheimer disease. Immunization with an amyloid β-peptide fragment reduces ...

1Missense mutations in the β-amyloid precursor protein (APP) or the presenilin ... mixtures of Aβ 1–42 and Aβ 1–40 (or fragments thereof), longer in vivo exposures, and other radioisotopes ...

This manuscript provides fundamental studies to help us better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP).

They demonstrated that a fragment of the amyloid precursor protein (APP), called APP-CTF, disrupts communication between cellular compartments crucial for calcium storage and waste disposal ...

Diagnosis and monitoring of sporadic Alzheimer's disease (AD) have long depended on clinical examination of individuals with end-stage disease. However, upcoming anti-AD therapies are optimally ...

Amyloid fibrils appear in many neurodegenerative diseases, and scientists are eager to understand how they form and spread. But amyloids—clumped aggregations of misfolded proteins—can be ...

In contrast, these tangles are rare in non-human primates and typically confined to small regions of the brain. Clumps of ...

In humans, harmful tau protein deposits, known as tau tangles, appear early in life and spread widely through the brain, ...