This study was supported by grants from Instituto de Salud Carlos III/FIS (PS09/00897, PI11/00556). E Ripoll received a fellowship from IDIBELL and Societat Catalana de Transplantament, and A ...

CD3-binding antibodies to widen the therapeutic window by generating TCEs with potent tumor-cell killing and optimal cytokine release Molecules to enhance efficacy for solid tumor indications by ...

VANCOUVER, British Columbia — AbCellera (Nasdaq: ABCL) today announced new data on its T-cell engager (TCE) platform, to be presented as a poster at the Society for Immunotherapy of Cancer (SITC) 39th ...

VANCOUVER, British Columbia — AbCellera (Nasdaq: ABCL) today announced new data on its T-cell engager (TCE) platform, to be presented as a poster at the Society for Immunotherapy of Cancer (SITC) 39th ...

1Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. 2Chemical Biology Laboratory, National Cancer Institute ...

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T cell activation requires engagement of a cognate antigen by the T cell receptor (TCR) and the co-stimulatory signal of CD28. Both TCR and CD28 aggregate into clusters at the plasma membrane of ...

Impact of stress on diseases including gastrointestinal failure is well-known, but molecular mechanism is not understood. Here we show underlying molecular mechanism using EAE mice. Under stress ...