The universal cell-cycle inhibitor p21 Cip1/WAF1 is phosphorylated ... Subcellular mislocalization of checkpoint controllers is now surfacing as a mechanism of deregulating cell proliferation ...

A review discussing the therapeutic potentials of NK cell biology has been published in the journal Frontiers of Medicine. This exhaustion is influenced by immune checkpoint receptors, which are ...

Dysregulated cell signaling underlies various diseases, emphasizing the importance of understanding these pathways for ...

Recursion expects to meet with FDA to discuss the potential of advancing REC-994 for treatment of patients with cerebral ...

This exhaustion is influenced by immune checkpoint receptors, which are inhibitory cell surface receptors that can suppress antitumor immunity. Notably, intracellular checkpoint molecules within ...

REC-1245 is designed to degrade the protein RBM39, which downregulates cell cycle checkpoints and DNA damage response networks.

Recursion announced that the first patient has been dosed in its Phase 1/2 clinical trial of REC-1245, a new chemical entity for the treatment ...

Open annotations (there are currently 0 annotations on this page). Cells regularly grow and divide through a process called the cell cycle. It includes rest periods where no growth or division occurs.

This exhaustion is influenced by immune checkpoint receptors, which are inhibitory cell surface receptors that can suppress antitumor immunity. Notably, intracellular checkpoint molecules within NK ...