Cytokinesis is a key event in the cell cycle requiring tight coordination of mitotic spindle assembly, actomyosin contractility and membrane dynamics, but the mechanisms that regulate cytokinesis are ...

The cellular life cycle, also called the cell cycle, includes many processes necessary for successful self-replication. Beyond carrying out the tasks of routine metabolism, the cell must duplicate ...

How is a normal cell transformed into a cancerous cell? The proteins involved in cell division events no longer appropriately drive progression from one cell cycle stage to the next. Cells that ...

This led to the identification of SAR020106 as a potent and selective inhibitor of CHK1 with in vivo activity in human tumour xenograft models and provided proof of both mechanism and concept for the ...