Nature14 天
Preparation and Identification of cis and trans Isomers of a Substituted Triarylethylene
U.K. patent No. 1013907. U.K. patent application No. 30755/65. Harper, M. J. K., and Walpole, A. L., Nature, 212, 87 (1966).
Chemistry World20 天
Cyclopropyl effect causes substituents on cyclohexane to favour axial conformation
He thinks the ‘really unusual stereocontrol element will be useful in a wide range of applications’, in particular in medicinal chemistry, ‘where the ability to extend groups into specific ...
C&EN25 天
Challenge for Deep Learning: Protein Structure Prediction of Ligand-Induced Conformational ...
Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, 43183 Gothenburg, Sweden ...
Phys.org29 天
Team develops deep learning model to predict protein conformational changes
More information: Yao Hu et al, Exploring Protein Conformational Changes Using a Large‐Scale Biophysical Sampling Augmented Deep Learning Strategy, Advanced Science (2024). DOI: 10.1002/advs ...
Phys.org1 个月
Chemists develop a metal-free way to selectively convert symmetrical diols into one of two ...
A team of chemists at the University of Cambridge has developed a metal-free way to convert symmetrical diols selectively into one of two mirror-image isomers. In their paper published in the ...
C&EN1 个月
Photoresponsive Organic Cages─Computationally Inspired Discovery of Azobenzene-Derived ...
Department of Chemistry and Materials Innovation Factory, University of Liverpool, 51 Oxford Street, Liverpool L7 3NY, U.K. Department of Chemistry and Materials Innovation Factory, University of ...
eLife9 年
Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways
These results suggest that together with other players in the Wnt signaling pathway, the conformational change of Dvl regulates Wnt stimulated JNK activity in the non-canonical Wnt signaling. The ...