引言在大脑的微观世界中，隐藏着人类智慧、感知与情感的奥秘。然而，这一复杂结构的发育和功能如何受到遗传变异的影响，仍是研究人员长期探讨的谜题。随着多能干细胞（pluripotent stem cells, ...

Researchers use cortical organoids to answer fundamental questions such as how the human brain can grow to its large size or ...

Last year, Muotri’s team showed for the first time that human stem cells grown into cortical organoids, so-called ‘mini brains’, could spontaneously produce human-like brain waves 3.“ ...

By combining morphological and single-cell level gene expression analyses, a team of researchers led by Professor Jun ...

The paper, by A. Amiri at Yale University in New Haven, CT, and colleagues was titled, "Transcriptome and epigenome landscape of human cortical development modeled in organoids." Advanced Search Home ...

My research is focused on using cerebral organoids to model aspects of human cortical development in vitro. I am improving on our current protocols to generate organoids that more accurately and ...

For example, there is a distinctly defined cortical plate on the surface of the organoids, with a central cavitation resembling a ventricle, the fluid filled spaces in the brain that produce and ...

However, the heterogeneity and low reproducibility of organoids present challenges to their scalable production, limiting their practical application in clinical trials and drug development processes.