Inotuzumab Ozogamicin and Low-Intensity Chemotherapy in Older Patients With Newly Diagnosed CD22+ Philadelphia Chromosome–Negative B-Cell Precursor Acute Lymphoblastic Leukemia We enrolled 16 patients ...

We enrolled 16 patients with PMC in a single-arm personalized cancer therapy trial. For all patients, tumor tissue and/or circulating tumor DNA genomic profiling using next-generation sequencing and, ...

CDK4–cyclin D1, CDK5–p35, His-tagged Erk1 and Erk2, protein kinase C isoforms, the catalytic subunit of cAPK, cGMP-dependent protein kinase, casein kinases 1 and 2, the insulin-receptor ...

隶属细胞周期蛋白依赖性激酶（Cyclin-dependent kinases, CDKs）的CDK8和CDK19通过调节信号诱导的特异性转录重编程，在细胞增殖和分化过程中发挥关键作用。

Investigators from the University of Michigan and affiliated organizations published data from a study that aimed to investigate the role of cyclin-dependent kinase 12 (CDK12) in prostate cancer (PCa) ...

Image Credit: Kateryna Kon/Shutterstock.com In a recent study published in Cell Reports Medicine, researchers investigated whether loss of the cyclin-dependent kinase 12 (CDK12) gene drives ...

A powerful, three-drug therapy for aggressive advanced breast cancer doubles the length of time before the cancer progresses, ...

Insilico Medicine Inc. has synthesized cyclin-dependent kinase 8/19 (CDK8/19) dual inhibitors reported to be useful for the treatment of autoimmune disease and cancer.

Title: INX-315, an oral, potent and selective CDK2 inhibitor in patients with CDK4/6 inhibitor resistant ER+/HER2- breast cancer or CCNE1 amplified solid tumors: phase 1 monotherapy dose escalation ...

The growth of the DEE treatment market can be attributed to the increasing prevalence of developmental and epileptic ...

Dr. Diehl’s research focuses on the molecular mechanisms of cancer initiation and progression with specific focus on the regulation of cell division and post-translational in cancer. The Diehl lab ...