Gut dysbiosis found to impair intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration
This disruption affects the signaling pathway involving FXR, which normally regulates bile acid synthesis and intestinal ...
Removing bile acid receptor in gut blocks intestinal inflammation, study shows
Removing a nuclear bile acid receptor that regulates glucose and lipid stability from the intestine blocks gut inflammation ...
Medscape1mon
The Vitamin D–antimicrobial Peptide Pathway and Its Role in Protection against Infection
It has been shown that primary bile acids are capable of inducing cathelicidin gene expression in biliary epithelial cells through the FXR. Secondary bile acids that are byproducts of metabolism ...
Medscape12d
NRF2 and FXR dual signaling pathways cooperatively regulate the effects of oleanolic acid on cholestatic liver injury.
The dual signaling pathways of NRF2 and FXR cooperatively regulate bile acid metabolic homeostasis through the interaction mechanism with β-catenin/P300.
GlobalData on MSN17d
Intercept loses Ocaliva FDA full approval bid in rare liver disease
Intercept’s US president Vivek Devaraj said the pharma company still believes in the evidence supporting the liver disease ...
Business Insider12d
Organovo announces oral presentation of FXR314
The meeting was held November 15-19, 2024 in San Diego, California. The presentation entitled “Pharmacokinetics, Safety and Efficacy of the Novel Non-bile Acid FXR Agonist FXR314 in Patients with ...
Organovo Presents Clinical Data of FXR314 in Phase 2 MASH in an Oral Presentation at The Liver Meeting
The presentation entitled “Pharmacokinetics, Safety and Efficacy of the Novel Non-bile Acid FXR Agonist FXR314 in Patients with Metabolic Dysfunction-Associated Steatohepatitis: Results from a Phase 2 ...