Results from a randomized phase 2 clinical trial show that adding high-dose, intravenous (IV) vitamin C to chemotherapy doubles the overall survival of patients with late-stage metastatic pancreatic ...

1Laboratoire Réparation et Transcription dans les cellules Souches, Institut de Radiobiologie Cellulaire et Moléculaire, CEA/DRF/Jacob/IRCM, INSERM U1274, Université Paris-Saclay, Université ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

If these troops detect harmful molecules being presented on the MHC-I radio masts, they kill the relevant cell. A requirement, however, is that the masts themselves are fully functional; otherwise, ...

Aishan Shih, RN, MS, Christine Miaskowski, RN, PhD, FAAN, Marylin J. Dodd, RN, PhD, FAAN, Nancy A. Stotts, RN, EdD, FAAN, Laurie MacPhail, PhD, DMD ...

Hematopoietic stem cell gene therapy (HSC-GT) represents a cutting-edge treatment strategy for multiple genetic disorders. By correcting genetic defects within hematopoietic stem cells (HSCs ...

P < 0.05, P < 0.01. (B) Bubble plot depicting the correlation between the top 5 weight-ranked gene features in the NPC-RSS (SMARCA2, DMC1, CD9, PSG4, KNG1) and tumor-immune-infiltrating cells in the ...

Once cells’ quality control mechanism is activated, IRGQ (red) accumulates in special cell organelles, the lsysosomes (green). This is also where the degradation of the non-functional MHC-I ...

The team then turned to single-cell RNA sequencing—a powerful technique to study gene activity in individual cells—to determine what genes were activated in the microglia of each mouse model.

"Studying stem cells in space has uncovered cell mechanisms that would otherwise ... Over time, space radiation could damage DNA and affect the growth of cells. Another concern is whether cells ...