Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein receptor (LDLR) at the surface of hepatocytes and accelerates its degradation in lysosomes, thereby impairing the ...

Doxorubicin also inhibited the expression of XBP1s, which prevented the induction of sufficient GRP78, leading to the activation of Caspase-12 and cell apoptosis. Doxorubicin also induced the cleavage ...

The work by Vallier and colleagues programmes ESCs and IPSCs towards hepatocyte fate by using a combination of hepatocyte transcription factors. Based on informatic analyses comparing adult ...

Here the authors identify that PTPN23 functions as a cell death checkpoint to restrain apoptosis, necroptosis and pyroptosis via regulating the endosomal sorting of death receptors and Toll-like ...