Here, we reveal the role of Ras-related protein Rab-2A (Rab2A) in mediating LD-Golgi interactions, thereby contributing to very-low-density lipoprotein (VLDL) lipidation and secretion in hepatocytes.
Importantly, the gene is linked to hepatocyte lipid accumulation and, by extension, to conditions like hepatic steatosis. Its loss-of-function mutation, rs72613567, results in a truncated ...
Steatotic liver disease is the overarching term for conditions characterised by abnormal lipid accumulation in the liver (liver or hepatic steatosis). Steatotic liver disease encompasses what was ...