Signal transduction across membranes through regulated intramembrane proteolysis is conserved throughout all domains of life. In the SREBP pathway of human cells, the membrane-bound SREBP ...

That led them to develop new receptors, now called SNIPRs (synthetic intramembrane proteolysis receptors), which can bind to ...

Postdoctoral fellow positions are available in the Laboratory of Biochemistry and Molecular Pharmacology at Memorial Sloan Kettering Cancer Center (MSKCC) to study regulated intramembrane proteolysis, ...

Researchers developed SNIPRs, innovative receptors that sense soluble ligands, enabling precise therapeutic control in CAR ...