Keywords: ion channels, transporters, Single-Molecule Imaging, Allosteric Modulation, Drug Design Important Note: All contributions to this Research Topic must be within the scope of the section and ...

Integral membrane proteins such as receptors and ion channels span the membrane ... The high-resolution structure of V-161 reveals its action on the Na+ transport pathway, offering new therapeutic ...

Here, the authors report the mGlu2-4 receptor structures in the inactive, intermediate and active states, and reveal the reason for the partial activity of the mono-liganded dimers. Bitter taste ...

A combination of methods, including a new method for tagging genes, demonstrates that the chemosensory co-receptors of Drosophila melanogaster (Orco, IR8a, IR25a, IR76b) are expressed widely and ...

Nov. 27, 2024 — Researchers have used a new gold-based drug to slow tumor growth in animals by 82% and target cancers more selectively than standard chemotherapy drugs, according to a new ...

30, 2024 — A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor ... in breast cancer cells that carry its receptors, but a new study unexpectedly finds ...

Facundo’s lab studies B-cell biology and antibody responses, particularly B-cell receptor signaling dynamics ... Daniel received his PhD in 2008 with work on ion channel signaling in sensory neurons ...

This study provides valuable evidence for the mechanism underlying KCNC1-related developmental and epileptic encephalopathy. The authors have generated and characterized a new knock-in mouse with a ...