From tumor necrosis factor alpha (TNF-α), to IL-17 inhibitors, and then to IL-23 inhibitors, biologics have brought new light ...

Monocytes and macrophages are myeloid cells that have important innate immune functions. Macrophages reside in tissues and respond to infection by producing inflammatory mediators and engulfing ...

Results The GCPM ecosystem coordinates a unique immunosuppressive pattern distinct from that of primary GC, which is dominated by a stroma-myeloid niche composed of SPP1+tumour-associated macrophages ...

DC-9476 has broad activity including decreasing macrophage activation, Th17 differentiation, IgG, and pro-inflammatory cytokines such as TNFα, IL-6, IL-17A and IL-17F. DC-9476 is expected to be ...

The immune response plays an important role in disease; however, immune-mediated mechanisms of pathogenesis and regulation are not understood. In this study, we determined that a pathogenic Th17 ...

Johannes Roth (CRC 1009), Michael Schäfers (CRC 1450), Jan Rossaint (CRU 342) The long road to hybrid parametric imaging in PET/MRI: Methodological challenges and implications for imaging of ...

2012). Primarily produced by monocytes, macrophages, and dendritic cells (DCs) in response to stimulation, IL-1β is involved in a variety of biological activities such as cell proliferation, ...

Impact of stress on diseases including gastrointestinal failure is well-known, but molecular mechanism is not understood. Here we show underlying molecular mechanism using EAE mice. Under stress ...