More importantly, they identified specific macrophage subpopulations that are critical for resolving MASH and liver fibrosis ...

Macrophage-myofibroblast transformation (MMT) transforms macrophages into myofibroblasts in a specific inflammation or injury microenvironment. MMT is an essential biological process in ...

School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China Macrophage-myofibroblast ...

Researchers developed novel genetic tools to trace, ablate, and manipulate p16^Ink4a+^ senescent cells, revealing their ...

More importantly, they identified specific macrophage subpopulations that are critical for resolving MASH and liver fibrosis ...

Liver-specific FGF21 overexpression was achieved in mice ... Moreover, FGF21 decreased lipid- and scar-associated macrophages, which correlated with less hepatic fibrosis as demonstrated by reduced ...

The hBMSCs implanted through one splenic injection of hBMSCs transdifferentiated into functional human hepatocytes and multiple immune cell lineages including B cells, T cells, natural killer cells, ...

With no effective treatments beyond liver transplants for these patients, RTX001 presents a first-in-class potential solution. RTX001 is an engineered, pro-regenerative macrophage therapy that ...

Macrophages act as effector cells of the innate immune system and play an important role in mediating inflammation and eliminating foreign organisms. RTX001 is designed to decrease fibrosis and ...