ACSL4 (acyl-CoA synthase long-chain family member 4), BSO (buthionine sulphoximine), DMT1 (divalent metal transporter 1), FSP1 (ferroptosis suppressor protein 1), FPN1 (ferroportin 1) GPX4 ...

该团队发现抑制GPX4或其它相关通路诱导铁死亡可显著缓解肿瘤生长和转移，并增强免疫治疗疗效（Gastroenterology 2024）。鉴于GPX4是调控铁死亡抵抗的 ...

铁死亡是一种铁依赖性的、非凋亡性、程序性细胞死亡，因其独特的机制在肿瘤治疗和神经退行性疾病领域引起广泛关注。中国科学院杭州医学研究所覃江江课题组长期致力于铁死亡调控肿瘤转移与免疫逃逸的分子机制及新药研发。2024年，该课题组与中国科学院 ...

Res, a Sirt1 agonist, upregulated Sirt1, which induced Nrf2 levels in SIC rats. A concentration of 25 μM Res was evaluated to have the greatest therapeutic effect and was used for all subsequent ...