Insulin resistance often is the primary metabolic abnormality ... leading to delayed and insufficient insulin secretion. Due to decreasing beta-cell function, the individual with insulin ...

Dysfunctions of the tiny cell ... produce insulin. This can lead to the development of type 2 diabetes (T2D). Current studies indicate that dysfunctions of the primary cilia of the beta cells ...

This study provides convincing evidence for functional subpopulations of β-cells responsible for Ca2+ signal initiation and maintenance using novel three-dimensional light sheet microscopy imaging and ...

To understand the root causes, diabetes mellitus is bifurcated into two primary categories: one involving a defect in insulin secretion and the other in insulin action. All different classifications ...

Some data suggest that increased apoptosis and decreased regeneration of beta cells are genetically programmed. Exaggerated insulin secretion ... will itself add to the primary therapeutic effect ...

The primary cilia observed in this study came from both animal and human beta cells. The researchers examined how the skeletal structure (axoneme) formed by microtubules is organized. They discovered ...