Insulin resistance often is the primary metabolic abnormality ... leading to delayed and insufficient insulin secretion. Due to decreasing beta-cell function, the individual with insulin ...

Dysfunctions of the tiny cell ... produce insulin. This can lead to the development of type 2 diabetes (T2D). Current studies indicate that dysfunctions of the primary cilia of the beta cells ...

Diabetes mellitus is characterized by the failure of insulin-secreting pancreatic ... revitalize and regenerate the remaining beta cells in diabetes patients. We are studying beta cell protective- and ...

To understand the root causes, diabetes mellitus is bifurcated into two primary categories: one involving a defect in insulin secretion and the other in insulin action. All different classifications ...

Our perspective about glucose toxicity as it pertains to the pancreatic ß-cell is that the characteristic decreases in insulin synthesis and secretion are caused by decreased insulin gene expression.

The primary cilia observed in this study came from both animal and human beta cells. The researchers examined how the skeletal structure (axoneme) formed by microtubules is organized. They discovered ...

half on a low-carbohydrate diet and the other half on a high-carbohydrate diet and examined their beta-cell function and insulin secretion at baseline and after 12 weeks. All of the participants ...