The canonical pyroptosis process is characterized by the inflammasome (typically NLRP3)-mediated activation of caspase-1, which in turn cleaves and activates IL-1β and IL-18, as well as gasdermin D, ...

Impact and progress Frontiers' impact Progress Report 2022 All progress reports ...

NLRP3 inflammasome activation, pro-inflammatory cytokine production and pyroptosis are key features of inflammation that contribute to liver fibrosis progression, cirrhosis and end-stage liver failure ...

【导读】环状RNA能够调节巨噬细胞的细胞质溶质性死亡（即细胞焦亡），这有可能促进炎症和基质金属蛋白酶（MMP）活性在腹主动脉瘤（AAA）中的协同作用。但环状RNA在调节AAA中巨噬细胞细胞质溶质性死亡方面的作用尚不明确。11月27日，南方医科大学何翔 ...

近日，中国科学院上海有机化学研究所生物与化学交叉研究中心许代超研究员在Cell Press细胞出版社期刊Trends in Cell Biology 发表了题为“Emerging roles of palmitoylation in pyroptosis”的综述 ... 将棕榈酸连接到靶蛋白半胱氨酸残基）在NLRP3炎症小体和GSDMD激活等多个层面 ...

据统计，全球范围内因脊髓损伤而致残的病患人数约有2700万，并且每年约有25万~50万新增患者，当前我国脊髓损伤患者超过370万人，并且以每年9万人的速度增长。 脊髓，是人体神经系统的核心 “指挥官”，负责传递大脑指令与身体各部位信息。

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ZyVersa Therapeutics (ZVSA) announces newly published data demonstrating that stroke-related cardiovascular injury and dysfunction is induced by AIM2 inflammasome activation and pyroptosis in the ...

Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL), a commercial stage biotechnology company focused on hematologic disorders and cancer, today announced that the U.S. Food and Drug Administration (FDA) has ...