【导读】环状RNA能够调节巨噬细胞的细胞质溶质性死亡（即细胞焦亡），这有可能促进炎症和基质金属蛋白酶（MMP）活性在腹主动脉瘤（AAA）中的协同作用。但环状RNA在调节AAA中巨噬细胞细胞质溶质性死亡方面的作用尚不明确。11月27日，南方医科大学何翔 ...

ZyVersa Therapeutics (ZVSA) announces newly published data demonstrating that stroke-related cardiovascular injury and dysfunction is induced by AIM2 inflammasome activation and pyroptosis in the ...

Shanghai Tenth People’s Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, Shanghai 200331, P. R. China Shanghai Tenth People’s Hospital, ...

It was further found that ZTY could inhibit the expression of ASC, Nlrp3, Caspase-1 and GSDMD mRNA in Caspase-1 mediated proptosis pathway. At the transcriptional level, ZTY can also inhibit the ...

Initial data from the ongoing Phase 1b study evaluating R289, a dual IRAK1/4 inhibitor, in LR-MDS Results show that while some patients with mIDH1 R/R AML achieve response to olutasidenib very quickly ...

Our previous study has demonstrated the inhibitory effects of cycloastragenol (CAG), an active form of astragaloside IV isolated from Astragalus membranaceus, on isoproterenol (ISO)-induced cardiac ...

Here, we demonstrated that ZIKV causes the pyroptosis of placental cells by activating the executor gasdermin E (GSDME) in vitro and in vivo. Mechanistically, TNF-α release is induced upon the ...

Intracellular lipopolysaccharide (LPS) triggers the non-canonical inflammasome pathway, resulting in pyroptosis of innate immune cells. In addition to its well-known ...