independent of mechanistic target of rapamycin complex 1 but involving the transcription factors TFEB and TFE3. Two broadly reactive and inhibitory human monoclonal antibodies against the malaria ...

Rapamycin, a natural compound, has shown anti-aging and health benefits in various researches. Consequently, the popularity and demand for rapamycin supplements have surged significantly in the ...

Autophagy receptor (or adaptor) proteins facilitate lysosomal destruction of various organelles in response to cellular stress, including nutrient deprivation. To what extent membrane-resident ...

The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a ...