This process involves the formation of autophagosomes that ultimately fuse with lysosomes to degrade cellular components. A key regulator of this process is Sirtuin 1 (SIRT1), which significantly ...

Sep. 25, 2024 — Adults with hemophilia B saw their number of bleeding episodes drop by an average of 71 percent after a single infusion of gene therapy, according to the new results of an ...

Capital structure describes the mix of a firm's long-term capital—a mix of debt and equity—that it uses to fund its ongoing operations and future growth. A company's capital structure is ...

The molecular players that mediate gene repression in LADs are currently unknown. Here, we performed FACS-based whole-genome genetic screens in human cells using LAD-integrated fluorescent reporters ...

Gene regulation refers to the mechanisms that ... A study finds a megadomain structure with a boundary at the Xist locus, preceding the well-known Dxz4-separated megadomains in somatic cells.

Similarly, the universities portfolio in Preclinical, and Discovery comprises 3, and 1 molecule. NAD-dependent deacetylase sirtuin-1 is a protein encoded by the SIRT1 gene. It modulates chromatin ...

Elizabeth Kellogg, PhD, St. Jude Department of Structural Biology, studied the structure of Fanzor2 to chart how these systems have evolved, offering key insights to inform future approaches to ...

A team led by Prof. Dr. Dirk Haller has demonstrated for the first time that defective mitochondria cause injuries in the intestinal epithelium and influence the microbiome. In this microscopic image ...