In 47 low-bias trials with 180,938 participants, the antioxidant supplements significantly increased mortality (RR, 1.05; 95% CI, 1.02-1.08). In low-bias risk trials, after exclusion of selenium ...
The results of two large clinical trials, which assessed the effects of antioxidant supplementation on cancer in men, have found no protective effect from vitamins C and E and selenium.