A group of essential signaling molecules known as the Wnt pathway emerged early in the evolution of multicellular life.

These signalling systems operate beyond cell and tissue boundaries, but function as morphogens that are secreted from one cell or tissue type to activate surface receptors, signal transduction ...

Finally, pathways such as Wnt signaling are very complex and involve a number of different ligands, receptors and endogenous antagonists and the activation of distinct intracellular signaling ...

For many years, scientists have known that genetic variants, or differences in DNA code across people, play some role in ...

Diffuse midline glioma (DMG) is a highly aggressive and fatal pediatric high-grade glioma that primarily affects critical ...

Allarity Therapeutics, Inc. (“Allarity” or the “Company”) (NASDAQ: ALLR), a clinical-stage pharmaceutical company ...

Dr. Gujral also works to develop better ways to screen potential cancer drugs. Noncanonical Wnt signaling pathway. Dr. Gujral’s lab explores how this pathway contributes to changes in cell state that ...

The regulation and remodeling of the tumor microenvironment (TME) are closely associated with how cancers typically progress ...

We now introduce an algorithm called Root Causal Strength using Perturbations (RCSP) that discovers the surrogate ancestors of each variable using Perturb-seq and then computes the RCS of each ...

TARRYTOWN, NY, USA I October 1, 2024 I Sapience Therapeutics, Inc., a clinical-stage biotechnology company focused on the discovery and development of peptide therapeutics to address oncogenic and ...

Former Eli Lilly Research Fellow Jeremy R. Graff, Ph.D., appointed as President and Chief Development Officer to lead the Company’s clinical ...

Neural stem cells (NSCs) play a crucial role in the progress of ischemic stroke. Research on zebrafish embryonic demonstrates an association between Strawberry Notch 1 (Sbno1) and central nervous ...