When they tested how different metabolites affected cDC1 cells, they saw an increase in the expression of genes linked to dendrite membranes and filopodia—tiny cell extensions that help the cell ...

When they tested how different metabolites affected cDC1 cells, they saw an increase in the expression of genes linked to dendrite membranes and filopodia -- tiny cell extensions that help the ...

癌细胞可以在体内被重新编程为免疫原性cDC1样抗原呈递细胞，可以激活T细胞并促进抗肿瘤免疫，克服了肿瘤微环境，化敌为友，为未来基于树突状细胞的免疫疗法铺平了道路。 癌症免疫治疗的成功取决于肿瘤特异性T细胞的启动。然而，肿瘤细胞经常下调抗原 ...

Myelopoiesis is the process in which innate immune cells, such as neutrophils, dendritic cells and monocytes, develop from a myeloid progenitor cell. The Irf8 +32-kb enhancer controls ...

We investigated a role of cDC1 in myeloma progression. Methods: A myeloma mouse model was performed by intravenous transplantation of Vk*MYC myeloma cells into XCR1-Diphtheria toxin receptor (DTR) ...

Taken together, these studies demonstrate that the presence of different DC subsets in the TME is correlated with cancer prognosis, with cDC1 and LAMP3 + DC mostly associated with a favorable ...

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction of effective CD8 + T cell immune responses. Here, we show that this ...