在一项新的研究中，来自德克萨斯大学西南医学中心的研究人员发现tRNA 可以决定 ...

科学家发现，转运 RNA (tRNA) 能够决定信使 RNA（mRNA）在细胞中的寿命，导致某些 mRNA 被稳定保存并翻译成更多的蛋白质，而另一些 mRNA 则被降解，从而限制蛋白质的生成量。

撰文丨王聪编辑丨王多鱼排版丨水成文众所周知，根据中心法则，DNA转录为mRNA，mRNA再翻译为蛋白质，mRNA的降解速率是每个基因产生的蛋白质的数量的主要决定因素，而这又会影响细胞功能。例如，对于mRNA疫苗，mRNA存在更长时间会产生更多蛋白质，从而更好地激活免疫系统以抵抗感染；而对于CRISPR-Cas9基因编辑，产生Cas9蛋白 ...

Scientists have discovered that tRNAs can determine how long mRNAs exist in a cell, causing some messages to be stabilized ...

Ribosomes, often referred to as the cell's protein factories, translate messenger RNA (mRNA) into a specific sequence of ...

Messenger RNA carries genetic information from DNA in the highly protected nucleus out to the rest of the cell, where structures called ribosomes can build proteins according to the DNA blueprint.

To make a protein, ribosomes don’t receive instructions directly from the unwieldy DNA, but from more succinct messenger RNA (mRNA) molecules that carry instructions about single genes.

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction ...