Osteoclast - Wikipedia
An osteoclast (from Ancient Greek ὀστέον (osteon) 'bone' and κλαστός (clastos) 'broken') is a type of bone cell that breaks down bone tissue. This function is critical in the maintenance, repair, and remodeling of bones of the vertebral skeleton.
Osteoclast biology in the single-cell era | Inflammation and ...
2022年9月2日 · Recent studies using single-cell technologies have uncovered the regulatory mechanisms underlying osteoclastogenesis at unprecedented resolution and shed light on the possibility that there is heterogeneity in the origin, function, and fate of osteoclast-lineage cells.
STAT3-mediated osteogenesis and osteoclastogenesis in …
2022年7月25日 · Osteoclastogenesis is a complex process that includes the regulation of various cytokines and the cell–cell fusion of osteoclast precursors. RANKL and macrophage-colony stimulating factor (M-CSF) are indispensable cytokines for osteoclast precursor differentiation and fusion into functional multinucleated giant cells [ 79 ].
Mechanisms involved in normal and pathological osteoclastogenesis …
2018年4月18日 · In this review, we provide an overview of signaling pathways and other regulatory elements governing osteoclastogenesis. We also identify how osteoclastogenesis is altered in pathological conditions and discuss therapeutic targets in osteoclasts for the treatment of skeletal diseases.
Recent advances in osteoclast biology | Histochemistry and
2018年2月1日 · In osteoclastogenesis, TAK1 activates inhibitory κB (IκB) kinases (IKKs) and mitogen-activated protein kinases (MAPKs) for further signaling. NF-κB signaling in osteoclastogenesis. NF-κB is one of the key transcription factors.
Role and Regulation of Transcription Factors in Osteoclastogenesis …
2023年11月10日 · In osteoclastogenesis, intercellular communication between osteoclasts and osteoblasts involves the transcription factors c-Fos and NFATC1, as well as M-CSF and RANKL, which regulate transcription factors.
Basic Aspects of Osteoclast Differentiation and Function
2020年2月1日 · Osteoclasts are multinucleated cells of the myeloid lineage that are highly specialized for bone resorption through acidification and exocytosis of bone-degrading enzymes into the space between the osteoclast and underlying bone, termed the resorption lacuna.
Osteoclastogenesis and Osteogenesis - MDPI
2022年6月15日 · This Special Issue of the International Journal of Molecular Sciences presents recent advances in our understanding of the molecular mechanisms underlying osteoclastogenesis and osteogenesis; these are the most basic, yet the most essential processes in bone remodeling and pathophysiology.
Regulation of Osteoclastogenesis and Bone Resorption by miRNAs
2021年6月17日 · A broader understanding of the regulatory mechanisms that govern osteoclastogenesis will facilitate development of novel therapeutic strategies for patients subjected to pathological bone resorption.
Editorial: Developmental Biology and Regulation of Osteoclasts
2021年10月21日 · Osteoclastogenesis is critical for maintaining bone architecture and integrity. While excessive bone resorption by osteoclasts is associated with osteoporosis and rheumatoid arthritis, impaired osteoclast differentiation and activity lead to osteopetrosis, a severe and often fatal condition (Sobacchi et al., 2013). Mutations in Sorting Nexin 10 ...