AH-7921 - Wikipedia
AH-7921 (Doxylam) is an opioid analgesic drug selective for the μ-opioid receptor, having around 90% the potency of morphine when administered orally. [2] [3] [4] It was discovered in the 1970s [5] by a team at Allen and Hanburys located in the United Kingdom. [6]
AH-7921: the list of new psychoactive opioids is expanded
AH-7921 is a structurally unique synthetic opioid analgesic that has recently entered the drug arena in Europe, the USA, and Japan. Although it was synthesized and patented in the mid-1970s, it was first identified in a seized sample purchased via the Internet in July 2012 and formally brought to th …
AH-7921: the list of new psychoactive opioids is expanded
2015年2月21日 · AH-7921 is a new, structurally atypical synthetic opioid analgesic that appears to be sold as a “research chemical” or “legal opioid” on the Internet since 2012. It was synthesized in the 1970s by Allen and Hanburys Ltd. as a potential analgesic medicine; however, its development was abandoned due to its addictive properties.
Metabolic characterization of AH-7921, a synthetic opioid …
AH-7921 (3,4-dichloro-N-[(1-dimethylamino)cyclohexylmethyl]benzamide) is a new synthetic opioid and has led to multiple non-fatal and fatal intoxications. To comprehensively study AH-7921 metabolism, we assessed human liver microsome (HLM) metabolic ...
AH-7921: A new synthetic opioid of abuse - Wiley Online …
2014年10月10日 · Since 2012, a new synthetic opioid named AH-7921 has become available within the recreational drug market 1. AH-7921, IUPAC name 3,4-dichloro-N-[[1-(dimethylamino)cyclohexyl]methyl]benzamide, is an N-substituted cyclohexylmethylbenzamide where the benzamide moiety is dichlorinated at positions 3 and 4 of the ring and the …
AH-7921: A review of previously published reports - PubMed
2018年6月1日 · AH-7921 is a synthetic opioid that was developed in the early 1970s. It has resulted in several fatal and nonfatal intoxications, despite not having approval from the US Food and Drug Administration. To date, AH-7921 is listed as a schedule I drug, and there have been no clinical trials exploring th …
AH-7921: the list of new psychoactive opioids is expanded
2015年8月10日 · AH-7921 is a structurally unique synthetic opioid analgesic that has recently entered the drug arena in Europe, the USA, and Japan.
AH-7921 - Expert Committee on Drug Dependence …
AH-7921 is a central nervous system depressant. In addition to analgesia, relaxation, euphoria, so-called opiate glow, and alertness, occasional itching, nausea and tremors have been described by self-reporting users. Various analytically confirmed non-fatal and fatal intoxications involving AH-7921 have been reported in the literature.
AH-7921: a new synthetic opioid of abuse - PubMed
AH-7921: a new synthetic opioid of abuse. AH-7921: a new synthetic opioid of abuse Drug Alcohol Rev. 2015 Jan;34(1):109-10. doi: 10.1111/dar.12216. Epub 2014 Oct 10. Authors Maurizio Coppola 1 , Raffaella Mondola. Affiliation 1 Department of Addiction, ASL CN2, Alba ...
AH-7921: A review of previously published reports - Taylor …
2018年6月1日 · AH-7921 is a synthetic opioid that was developed in the early 1970s. It has resulted in several fatal and nonfatal intoxications, despite not having approval from the US Food and Drug Administration. To date, AH-7921 is listed as a schedule I drug, and there have been no clinical trials exploring the safety of AH-7921.