Cyclin-dependent kinases | Genome Biology | Full Text
2014年6月30日 · Handschick K, Beuerlein K, Jurida L, Bartkuhn M, Muller H, Soelch J, Weber A, Dittrich-Breiholz O, Schneider H, Scharfe M, Jarek M, Stellzig J, Schmitz ML, Kracht M: Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-kappaB-dependent gene expression.
Cyclin-dependent kinases - PubMed
Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cu …
The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression …
The cyclin/CDKs themselves are negatively regulated by cyclin-dependent kinase inhibitors (CKIs), such as the inhibitor of CDK4 (INK4) proteins (p16 INK4a, p15 INK4b, p18 INK4c, and p19 INK4d), and CDK-interacting protein/kinase inhibitory proteins …
Cyclin-Dependent Kinase - an overview | ScienceDirect Topics
2018年9月16日 · The cyclin-dependent kinases are a family of serine threonine kinases that require binding to regulatory subunits called cyclins (or in some cases a non-cyclin) for their actions (Malumbres, 2014). There are 21 human CDKs numbered from 1 to 20 (including a CDK11A and CDK11B, which are encoded by separate genes) and 29 cyclins.
CDK | Learn Science at Scitable - Nature
Cyclin-dependent kinases (CDKs) trigger the transition from G1 to S phase and from G2 to M phase by phosphorylating distinct sets of substrates.
The Cyclin-dependent kinase 1: more than a cell cycle regulator
2023年10月28日 · The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to carry...
Cyclin-dependent kinases: a family portrait | Nature Cell Biology
Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin...
Cyclin-dependent kinases: a family portrait - PMC - PubMed …
Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits.
Cyclin-Dependent Kinase - an overview | ScienceDirect Topics
The cyclin-dependent kinase (CDK) family of serine/threonine kinases regulate progression through each stage of the cell division cycle and as such are major targets for deregulation in cancer. This has led to the development of several small-molecule inhibitors of CDKs as potential therapeutic agents for the treatment of this disease.
Cyclins and cyclin-dependent kinases: from biology to ... - Springer
2022年7月4日 · If any perturbation is detected in each stage, these checkpoints transmit a signal to a group of proteins named cyclin-dependent kinase (CDK) inhibitors to block the progression of the cell cycle (Musacchio and Salmon 2007; Williams and Stoeber 2012).
- 某些结果已被删除