HEALTH EFFECTS - Toxicological Profile for Styrene - NCBI Bookshelf
The rates of metabolism of styrene by cytochromes P-450 CYP2E1 and CYP2F2 to styrene oxide was similar for the two species. However, styrene oxide is more efficiently metabolized by epoxide hydrolases and glutathione S-transferases in rats than in mice.
Mechanistic and Other Relevant Data - Styrene, Styrene-7,8 …
Absorption, distribution, metabolism, and excretion. Styrene is extensively metabolized to styrene-7,8-oxide in humans and in experimental systems. As a result, external exposures to styrene engender internal exposures to both styrene and styrene-7,8-oxide.
Frontiers | A Review: The Styrene Metabolizing Cascade of Side …
2018年3月21日 — This review elucidates the most important degradations pathways and discussed the biotechnological potential of the route designated as side-chain oxygenation. The enzymes of this pathways as well as the pathway itself allow the production of styrene oxides, phenylacetaldehydes or phenylacetic acids (Tischler, 2015).
A Review: The Styrene Metabolizing Cascade of Side-Chain
2018年3月22日 — The natural occurrence of styrene led to several microbiological strategies to form and also to degrade styrene. One pathway designated as side-chain oxygenation has been reported as a specific route for the styrene degradation among microorganisms.
Microbial Styrene Degradation: From Basics to Biotechnology
2011年1月1日 — Styrene, the simplest representative of alkenylbenzenes, is one of the most important monomers produced by the chemical industry today. The compound shows a distinct toxicological behavior and is classified as a possible carcinogen due to its metabolism in human via a highly mutagenic epoxide.
Bacteria are able to metabolize u- and 0-styrene as well as styrene dimers and tetramers, although higher oligomers of styrene are recalci- trant. Styrene-degrading organisms have been used in experimental gas filters, and chiral synthetic precursors based on styrene can be produced using microbial enzymes. 1.
Exploring the styrene metabolism by aerobic bacterial isolates …
The metabolism of styrene in aerobic bacteria occurs via two types of pathways: lower and upper pathways; the former pathway involves vinyl side chain oxidation that converts styrene to phenylacetic acid, and the latter pathway involves the degradation of phenylacetic acid. 14,32 The enzymes in the organism play a crucial role in the metabolism ...
Microbial degradation of styrene: biochemistry, molecular …
2006年7月6日 — Consequently, mammalian and microbial metabolism of styrene has received a lot of attention in the last 25 years. We will focus, in this review, on the microbial metabolism and transformation of styrene and look at potential biotechnological applications of microorganism that degrade styrene.
Microbial metabolism and biotransformations of styrene
1995年1月1日 — Bacteria are able to metabolize alpha- and beta-styrene as well as styrene dimers and tetramers, although higher oligomers of styrene are recalcitrant. Styrene-degrading organisms have been...
Metabolism and Genotoxicity of Styrene | SpringerLink
2012年10月15日 — In human whole blood cultures, styrene is metabolized into styrene-7,8-oxide. Styrene is able to induce both SCEs and chromosomal aberrations in cultured lymphocytes. The clastogenic action of styrene can be explained by the metabolism of styrene into styrene-7,8-oxide in cultured human blood cells.
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