Inhibition of autophagy and MEK promotes ferroptosis in Lkb1
2023年1月26日 · We found that the combination of the autophagy inhibitor hydroxychloroquine (HCQ) and the MEK inhibitor Trametinib displays synergistic anti-proliferative activity in KrasG12D/+;Lkb1-/- (KL)...
Redefining the role of AMPK in autophagy and the energy stress …
2023年5月24日 · During an energy crisis caused by mitochondrial dysfunction, the LKB1-AMPK axis inhibits ULK1 activation and autophagy induction, even under amino acid starvation.
Autophagy compensates for Lkb1 loss to maintain adult mice
2020年11月25日 · Liver kinase B1 (LKB1), also known as serine/threonine kinase 11 (STK11) is the major energy sensor for cells to respond to metabolic stress. Autophagy degrades and recycles proteins, macromolecules, and organelles for cells to survive starvation.
LKB1 biology: assessing the therapeutic relevancy of LKB1 …
2024年6月6日 · Given that previous reviews have dissected LKB1-AMPK signalling pathways [62, 63], this review will focus on the importance of the LKB1-AMPK axis to cell polarity, migration, metabolism, and autophagy. Genetic screens of Drosophila melanogaster oocyte mutants linked LKB1 to epithelial follicle cell polarity.
LKB1 regulates autophagy through AMPK/TOR signaling pathway …
Further studies conclusively showed that silencing LvLKB1 inhibited AMPK phosphorylation induced by V. alginolyticus infection, thereby activating TOR pathway and inhibiting autophagy in shrimp. These results indicate that LvLKB1 regulates autophagy through AMPK/TOR signaling pathway to alleviate the damage caused by V. alginolyticus infection.
Autophagy modulates lipid metabolism to maintain metabolic …
2019年2月1日 · Autophagy is a protective process involving self-cannibalization to maintain cellular energy homeostasis during nutrient deprivation. We developed a mouse model for Lkb1 -deficient lung cancer with conditional deletion of essential autophagy gene Atg7 to test whether autophagy compensates for LKB1 loss for tumor cells to survive energy crises.
Insights into targeting LKB1 in tumorigenesis - ScienceDirect
2024年8月28日 · However, the role of LKB1 in tumorigenesis is paradoxical as LKB1 activates autophagy and reactive oxygen species scavenging while dampening anoikis, which contribute to cancer cell survival. Due to the pro-tumorigenic properties of LKB1, targeting LKB1 pathways is now relevant for cancer treatment.
LKB1 regulates autophagy through AMPK/TOR signaling pathway …
2024年4月1日 · The results from qRT-PCR, WB, flow cytometry, and electron microscopy observations of cell ultrastructure all indicate that silencing LKB1 can inhibit the level of autophagy in shrimp hepatopancreas after V. alginolyticus infection. LKB1 is a key upstream kinase that activates the central metabolic regulator AMP-activated protein kinase (AMPK).
CXCL17 promotes cell metastasis and inhibits autophagy via the LKB1 …
2019年3月30日 · CXCL17 expression promotes the translocation of LKB1 from the cytoplasm to the nucleus, which prohibited AMPK stimulation and suppressed autophagy and promoted proliferation. Therefore, our study is the first to show that CXCL17 can regulate proliferation, migration, and autophagy in HCC and that the LKB1-AMPK axis participates in this reaction.
The LKB1–AMPK pathway: metabolism and growth control in
LKB1 acts a master upstream kinase, directly phosphorylating and activating AMP-activated protein kinase (AMPK) and a family of 12 related kinases that have crucial roles in cell growth,...
- 某些结果已被删除