Sirtuin 1 - Wikipedia
Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes.
The Beneficial Roles of SIRT1 in Neuroinflammation-Related …
2020年9月14日 — Among seven sirtuins, SIRT1 plays a critical role in modulating a wide range of physiological processes, including apoptosis, DNA repair, inflammatory response, metabolism, cancer, and stress.
The Role of Sirtuin 1 (SIRT1) in Neurodegeneration - PMC
2023年6月15日 — The human SIRT1 gene is found on chromosome 10q22.1 with nine exons and eight introns, which produces a 747-amino acid residue protein. It is made up of the conserved catalytic core and the nuclear localization signal KRKKRK, identifying it as a nuclear protein.
Sirtuin 1 (SIRT1): the misunderstood HDAC - PubMed
Histone Deacetylase Inhibitors. Sirtuin 1. The sirtuin family of NAD-dependent histone deacetylases (HDACs) consists of seven mammalian proteins, SIRT1-7. Many of the sirtuin isoforms also deacetylate nonhistone substrates, such as p53 (SIRT1) and α-tubulin (SIRT2).
Emerging roles of SIRT1 activator, SRT2104, in disease treatment
2024年3月6日 — Silent information regulator 1 (SIRT1) is a NAD+-dependent class III deacetylase that plays important roles in the pathogenesis of numerous diseases, positioning it as a prime candidate for...
SIRT1: A Potential Therapeutic Target in Autoimmune Diseases
2021年11月23日 — The activator of SIRT1 plays a protective role in pristane-induced lupus mice, with the alleviation of proteinuria and decreased deposition of immune globulin in the kidneys (14). SIRT1 also may represent a biomarker of relapses and a potential target for therapeutic intervention in MS (15).
SIRT1 is a regulator of autophagy: Implications for the …
2024年1月1日 — SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD +)-dependent histone deacetylase. It is involved in the regulation of various pathophysiological processes, including cell proliferation, survival, differentiation, autophagy, and oxidative stress.
Sirtuin 1 regulates the phenotype and functions of dendritic cells ...
5 天之前 — Protein-Protein Interaction Networks Functional Enrichment Analysis (STRING) revealing high scores of confidence (>0.900) for PPARγ and interaction with SIRT1 in mice (G) and human (H).
Sirtuin 1 (SIRT1) and Oxidative Stress - SpringerLink
2014年1月1日 — Sirtuin 1 (SIRT1) is a NAD+-dependent histone/protein deacetylase that regulates a variety of cellular functions such as genome maintenance, longevity, and metabolism. This chapter focuses on the functions of SIRT1 in the context of oxidative stress.
The Role of Sirtuin-1 (SIRT1) in the Physiology and ... - MDPI
2023年11月11日 — Sirtuin-1 (SIRT1) acts primarily by removing acetyl groups from lysine residues within substrate proteins in the presence of nicotinamide adenine diphosphate (NAD+). The NAD+ dependence determines that the levels of …