5-HT2C Receptor - an overview | ScienceDirect Topics
The 5-HT2C receptor is a type of receptor that is found in certain parts of the human brain, including the choroid plexus, prefrontal cortex, and limbic structures. It is a type of postsynaptic receptor that is associated with G-protein coupled receptors and has excitatory effects.
Editorial: Contemporary Perspective on 5-HT2C Receptor …
The 5-HT 2C R is indeed an intriguing and fascinating G protein-coupled receptor (GPCR) with amazing regulatory features devised by biology, including its pre-transcriptional regulation, alternative splice variants and post-transcriptional RNA editing.
Targeting the 5-HT2C Receptor in Biological Context and the …
The 5-HT 2C receptor (5-HT 2C R), a receptor subtype in the 5-HT 2 R family (5-HT 2A R, 5-HT 2B R, 5-HT 2C R) has been increasingly investigated as a therapeutic target in recent years.
5-Hydroxytryptamine Receptor 2C - SpringerLink
2018年1月1日 · 5-HT2C receptors expressed along ascending dopaminergic pathways play a prominent role in the control of mesocorticolimbic and nigrostriatal dopaminergic systems. Constitutive and/or agonist-induced 5-HT2C receptor activation inhibits dopamine release (Berg et al. 2008; Bubar and Cunningham 2008).
Targeting the 5-HT2C Receptor in Biological Context and the …
Serotonin (5-HT) 5-HT2C receptor (5-HT2CR) is recognized as a critical mediator of diseaserelated pathways and behaviors based upon actions in the central nervous system (CNS).
5-HT2C receptors in psychiatric disorders: A review
2016年4月3日 · The development of drugs that specifically target 5-HT2C receptors will allow for better understanding of their involvement in the pathophysiology of psychiatric disorders including schizophrenia, anxiety, and depression.
5-HT2C Receptor - an overview | ScienceDirect Topics
Like the 5-HT 2A receptor, the 5-HT 2C receptor is a primarily postsynaptic excitatory G-protein-coupled receptor mediating many aspects of 5-HT function. 5-HT 2C receptors have their highest density in the choroid plexus, but are found in basal ganglia and limbic regions of the brain, where they may also be involved in the effects of some of ...
A short history of the 5-HT2C receptor: from the choroid plexus …
This paper is a personal account on the discovery and characterization of the 5-HT 2C receptor (first known as the 5-HT 1C receptor) over 30 years ago and how it translated into a number of unsuspected features for a G protein-coupled receptor (GPCR) and a …
5-HT2C Receptor Structures Reveal the Structural Basis of …
2018年2月2日 · Here we solved two structures of the 5-HT 2C receptor in complex with the highly promiscuous agonist ergotamine and the 5-HT 2A-C receptor-selective inverse agonist ritanserin, at resolutions of 3.0 Å and 2.7 Å, respectively.
Positive-allosteric modulation of the 5-HT2C receptor ... - Nature
2018年9月10日 · The 5-HT 2C receptor (5-HT 2C R) is a G protein-coupled receptor (GPCR) that has been implicated in psychiatric and neurological disorders, including anxiety, depression, schizophrenia,...
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