肿瘤免疫靶点 | CD28 - 知乎 - 知乎专栏
作为靶向cd28拮抗剂单抗药物，fr104靶向cd28配体结合基序重叠表位mypppy，抑制cd28与b7-1/ b7-2的结合途径，下调效应t细胞，同时能促进调节性t细胞（t-reg）活性。
【靶点聚焦】B7-CD28超家族：T细胞活化与增殖的“开关”_ACROBi…
2021年5月12日 · 其中主要的协同刺激信号途径是B7-CD28超家族，通过CD28受体家族与B7配体家族相互作用，激活或抑制T细胞的活化与增殖。. 因此B7家族在肿瘤免疫、自身免疫病和器官移植的临床治疗中发挥着十分重要作用。. 尤其是在百家争鸣的肿瘤免疫治疗中，B7家族一直备受 ...
Recent advancements in the B7/CD28 immune checkpoint …
2023年4月17日 · The B7/CD28 families of immune checkpoints play vital roles in negatively or positively regulating immune cells in homeostasis and various diseases. Recent basic and clinical studies have...
The B7:CD28 family and friends: Unraveling coinhibitory interactions
2024年2月13日 · Costimulatory pathways within the B7:CD28 family provide essential signals for optimal T cell activation and clonal expansion. They provide crucial inhibitory signals that maintain immune homeostasis, control resolution of inflammation, regulate host defense, and promote tolerance to prevent autoimmunity.
The B7–CD28 superfamily - Nature Reviews Immunology
The B7-1/B7-2–CD28/CTLA-4 co-stimulatory pathway has a crucial role in regulating T-cell activation and tolerance. New B7 and CD28 family members and new pathways have recently been...
The Role of the CD28 Family Receptors in T-Cell Immunomodulation
2024年1月20日 · Proteins from the B7 family of ligands engage the receptors of the CD28 family. These ligand–receptor pairs that exert inhibitory or stimulatory effects on immune responses are immune checkpoint molecules, crucial for maintaining self-tolerance and modulating the length and magnitude of immune responses.
Recent advancements in the B7/CD28 immune checkpoint …
2023年4月17日 · The B7/CD28 families of immune checkpoints play vital roles in negatively or positively regulating immune cells in homeostasis and various diseases. Recent basic and clinical studies have revealed novel biology of the B7/CD28 …
The CD28-B7 Family in Anti-Tumor Immunity: Emerging Concepts in Cancer …
2014年12月22日 · The interactions between B7 molecules and CD28-family receptors are crucial in the regulation of adaptive cellular immunity. In cancer, the aberrant expression of co-inhibitory B7 molecules has been attributed to reduced anti-tumor immunity and cancer immune evasion, prompting the development of cancer therapeutics that can restore T cell ...
B7 (protein) - Wikipedia
B7 is a type of integral membrane protein found on activated antigen-presenting cells (APC) that, when paired with either a CD28 or CD152 surface protein on a T cell, can produce a costimulatory signal or a coinhibitory signal to enhance or decrease the activity of a MHC-TCR signal between the APC and the T cell, respectively.
T-cell regulation by CD28 and CTLA-4 - Nature
2001年12月1日 · CD28 is the best characterized and most effective co-stimulatory molecule expressed by naive and primed T cells. CD28 is a 44-kDa glycoprotein that binds to B7-1 (CD80) and B7-2 (CD86) on...